Antirheumatic Disease Therapies for the Treatment of COVID-19: A Systematic Review and Meta-analysis.
Identifieur interne : 001689 ( Main/Exploration ); précédent : 001688; suivant : 001690Antirheumatic Disease Therapies for the Treatment of COVID-19: A Systematic Review and Meta-analysis.
Auteurs : Michael Putman [États-Unis] ; Yu Pei Eugenia Chock [États-Unis] ; Herman Tam [Canada] ; Alfred H J. Kim [États-Unis] ; Sebastian E. Sattui [États-Unis] ; Francis Berenbaum [France] ; Maria I. Danila [États-Unis] ; Peter Korsten [Allemagne] ; Catalina Sanchez-Alvarez [États-Unis] ; Jeffrey A. Sparks [États-Unis] ; Laura C. Coates [Royaume-Uni] ; Candace Palmerlee ; Andrea Peirce [Royaume-Uni] ; Arundathi Jayatilleke [États-Unis] ; Sindhu R. Johnson [Canada] ; Adam Kilian [États-Unis] ; Jean Liew [États-Unis] ; Larry J. Prokop [États-Unis] ; M Hassan Murad [États-Unis] ; Rebecca Grainger [Nouvelle-Zélande] ; Zachary S. Wallace [États-Unis] ; Alí Duarte-García [États-Unis]Source :
- Arthritis & rheumatology (Hoboken, N.J.) [ 2326-5205 ] ; 2020.
Abstract
OBJECTIVE
Antirheumatic disease therapies have been used to treat coronavirus disease 2019 (COVID-19) and its complications. We conducted a systematic review and meta-analysis to describe the current evidence.
METHODS
A search of published and preprint databases in all languages was performed. Included studies described one or more relevant clinical outcomes in five or more people who were infected with SARS-CoV-2 and were treated with antirheumatic disease therapy between 01/01/2019 and 05/29/2020. Pairs of reviewers screened articles and extracted data and assessed risk of bias. A meta-analysis of effect sizes using the random-effects models was performed when possible.
RESULTS
The search identified 3,935 articles, of which 45 were included (4 randomized controlled trials, 29 cohort studies, and 12 case series). All studies evaluated hospitalized patients and 29 out of 45 had been published in a peer-reviewed journal. In a meta-analysis of three cohort studies with a low risk of bias, hydroxychloroquine use was not significantly associated with mortality (pooled hazard ratio (HR) 1.41, 95% confidence interval (CI) 0.83-2.42). In a meta-analysis of two cohort studies with some concerns/high risk of bias, anakinra use was associated with lower mortality (pooled HR 0.2, 95% CI 0.1-0.4). Evidence was inconclusive with regard to other antirheumatic disease therapies and the majority of other studies had a high risk of bias.
CONCLUSION
In this systematic review and meta-analysis, hydroxychloroquine use was not associated with benefit or harm with regard to COVID-19 mortality. The evidence supporting the effect of other antirheumatic disease therapies in COVID-19 is currently inconclusive.
DOI: 10.1002/art.41469
PubMed: 32741139
PubMed Central: PMC7435536
Affiliations:
- Allemagne, Canada, France, Nouvelle-Zélande, Royaume-Uni, États-Unis
- Alabama, Angleterre, Basse-Saxe, Connecticut, District de Columbia, Illinois, Massachusetts, Minnesota, Missouri (État), Ontario, Oxfordshire, Pennsylvanie, Washington (État), État de New York, Île-de-France
- Göttingen, Oxford, Paris, Saint-Louis (Missouri), Seattle, Toronto
- Université d'Oxford, Université de Toronto, Université de Washington, École de médecine (Université Washington de Saint-Louis)
Links toward previous steps (curation, corpus...)
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Danila</name><affiliation wicri:level="2"><nlm:affiliation>University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Korsten, Peter" sort="Korsten, Peter" uniqKey="Korsten P" first="Peter" last="Korsten">Peter Korsten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Sanchez Alvarez, Catalina" sort="Sanchez Alvarez, Catalina" uniqKey="Sanchez Alvarez C" first="Catalina" last="Sanchez-Alvarez">Catalina Sanchez-Alvarez</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Sparks, Jeffrey A" sort="Sparks, Jeffrey A" uniqKey="Sparks J" first="Jeffrey A" last="Sparks">Jeffrey A. Sparks</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Coates, Laura C" sort="Coates, Laura C" uniqKey="Coates L" first="Laura C" last="Coates">Laura C. Coates</name><affiliation wicri:level="4"><nlm:affiliation>Patient Research Partner and Nuffield, Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Patient Research Partner and Nuffield, Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Palmerlee, Candace" sort="Palmerlee, Candace" uniqKey="Palmerlee C" first="Candace" last="Palmerlee">Candace Palmerlee</name><affiliation><nlm:affiliation>Patient Research Partner and Orthopedic Manual Therapist, Private Practice, Berkeley, CA, United Kingdom of Great Britain and Northern Ireland.</nlm:affiliation><wicri:noCountry code="subField">United Kingdom of Great Britain and Northern Ireland</wicri:noCountry></affiliation></author><author><name sortKey="Peirce, Andrea" sort="Peirce, Andrea" uniqKey="Peirce A" first="Andrea" last="Peirce">Andrea Peirce</name><affiliation wicri:level="3"><nlm:affiliation>Patient Research Partner, USA, Oxford.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><wicri:orgArea>Patient Research Partner, USA</wicri:orgArea></affiliation></author><author><name sortKey="Jayatilleke, Arundathi" sort="Jayatilleke, Arundathi" uniqKey="Jayatilleke A" first="Arundathi" last="Jayatilleke">Arundathi Jayatilleke</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Johnson, Sindhu R" sort="Johnson, Sindhu R" uniqKey="Johnson S" first="Sindhu R" last="Johnson">Sindhu R. Johnson</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital; Institute of health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital; Institute of health Policy, Management and Evaluation, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kilian, Adam" sort="Kilian, Adam" uniqKey="Kilian A" first="Adam" last="Kilian">Adam Kilian</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Liew, Jean" sort="Liew, Jean" uniqKey="Liew J" first="Jean" last="Liew">Jean Liew</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Prokop, Larry J" sort="Prokop, Larry J" uniqKey="Prokop L" first="Larry J" last="Prokop">Larry J. Prokop</name><affiliation wicri:level="2"><nlm:affiliation>Library Public Services, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Library Public Services, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Murad, M Hassan" sort="Murad, M Hassan" uniqKey="Murad M" first="M Hassan" last="Murad">M Hassan Murad</name><affiliation wicri:level="2"><nlm:affiliation>Evidence-Based Practice Center, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Evidence-Based Practice Center, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Grainger, Rebecca" sort="Grainger, Rebecca" uniqKey="Grainger R" first="Rebecca" last="Grainger">Rebecca Grainger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Otago, Wellington, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Otago, Wellington</wicri:regionArea><wicri:noRegion>Wellington</wicri:noRegion></affiliation></author><author><name sortKey="Wallace, Zachary S" sort="Wallace, Zachary S" uniqKey="Wallace Z" first="Zachary S" last="Wallace">Zachary S. Wallace</name><affiliation wicri:level="2"><nlm:affiliation>Clinical Epidemiology Program, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Epidemiology Program, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Duarte Garcia, Ali" sort="Duarte Garcia, Ali" uniqKey="Duarte Garcia A" first="Alí" last="Duarte-García">Alí Duarte-García</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32741139</idno><idno type="pmid">32741139</idno><idno type="doi">10.1002/art.41469</idno><idno type="pmc">PMC7435536</idno><idno type="wicri:Area/Main/Corpus">000753</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000753</idno><idno type="wicri:Area/Main/Curation">000753</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000753</idno><idno type="wicri:Area/Main/Exploration">000753</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antirheumatic Disease Therapies for the Treatment of COVID-19: A Systematic Review and Meta-analysis.</title><author><name sortKey="Putman, Michael" sort="Putman, Michael" uniqKey="Putman M" first="Michael" last="Putman">Michael Putman</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern Medicine, Division of Rheumatology, Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Northwestern Medicine, Division of Rheumatology, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Chock, Yu Pei Eugenia" sort="Chock, Yu Pei Eugenia" uniqKey="Chock Y" first="Yu Pei Eugenia" last="Chock">Yu Pei Eugenia Chock</name><affiliation wicri:level="2"><nlm:affiliation>Section of Rheumatology, Yale School of Medicine, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Rheumatology, Yale School of Medicine, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Tam, Herman" sort="Tam, Herman" uniqKey="Tam H" first="Herman" last="Tam">Herman Tam</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, The Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Alfred H J" sort="Kim, Alfred H J" uniqKey="Kim A" first="Alfred H J" last="Kim">Alfred H J. Kim</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Sattui, Sebastian E" sort="Sattui, Sebastian E" uniqKey="Sattui S" first="Sebastian E" last="Sattui">Sebastian E. Sattui</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Berenbaum, Francis" sort="Berenbaum, Francis" uniqKey="Berenbaum F" first="Francis" last="Berenbaum">Francis Berenbaum</name><affiliation wicri:level="3"><nlm:affiliation>Department of Rheumatology, Sorbonne Université, INSERM CRSA, AP-HP Hopital Saint Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Sorbonne Université, INSERM CRSA, AP-HP Hopital Saint Antoine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Danila, Maria I" sort="Danila, Maria I" uniqKey="Danila M" first="Maria I" last="Danila">Maria I. Danila</name><affiliation wicri:level="2"><nlm:affiliation>University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Korsten, Peter" sort="Korsten, Peter" uniqKey="Korsten P" first="Peter" last="Korsten">Peter Korsten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Sanchez Alvarez, Catalina" sort="Sanchez Alvarez, Catalina" uniqKey="Sanchez Alvarez C" first="Catalina" last="Sanchez-Alvarez">Catalina Sanchez-Alvarez</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Sparks, Jeffrey A" sort="Sparks, Jeffrey A" uniqKey="Sparks J" first="Jeffrey A" last="Sparks">Jeffrey A. Sparks</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Coates, Laura C" sort="Coates, Laura C" uniqKey="Coates L" first="Laura C" last="Coates">Laura C. Coates</name><affiliation wicri:level="4"><nlm:affiliation>Patient Research Partner and Nuffield, Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Patient Research Partner and Nuffield, Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Palmerlee, Candace" sort="Palmerlee, Candace" uniqKey="Palmerlee C" first="Candace" last="Palmerlee">Candace Palmerlee</name><affiliation><nlm:affiliation>Patient Research Partner and Orthopedic Manual Therapist, Private Practice, Berkeley, CA, United Kingdom of Great Britain and Northern Ireland.</nlm:affiliation><wicri:noCountry code="subField">United Kingdom of Great Britain and Northern Ireland</wicri:noCountry></affiliation></author><author><name sortKey="Peirce, Andrea" sort="Peirce, Andrea" uniqKey="Peirce A" first="Andrea" last="Peirce">Andrea Peirce</name><affiliation wicri:level="3"><nlm:affiliation>Patient Research Partner, USA, Oxford.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><wicri:orgArea>Patient Research Partner, USA</wicri:orgArea></affiliation></author><author><name sortKey="Jayatilleke, Arundathi" sort="Jayatilleke, Arundathi" uniqKey="Jayatilleke A" first="Arundathi" last="Jayatilleke">Arundathi Jayatilleke</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Johnson, Sindhu R" sort="Johnson, Sindhu R" uniqKey="Johnson S" first="Sindhu R" last="Johnson">Sindhu R. Johnson</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital; Institute of health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital; Institute of health Policy, Management and Evaluation, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kilian, Adam" sort="Kilian, Adam" uniqKey="Kilian A" first="Adam" last="Kilian">Adam Kilian</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Liew, Jean" sort="Liew, Jean" uniqKey="Liew J" first="Jean" last="Liew">Jean Liew</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Prokop, Larry J" sort="Prokop, Larry J" uniqKey="Prokop L" first="Larry J" last="Prokop">Larry J. Prokop</name><affiliation wicri:level="2"><nlm:affiliation>Library Public Services, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Library Public Services, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Murad, M Hassan" sort="Murad, M Hassan" uniqKey="Murad M" first="M Hassan" last="Murad">M Hassan Murad</name><affiliation wicri:level="2"><nlm:affiliation>Evidence-Based Practice Center, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Evidence-Based Practice Center, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Grainger, Rebecca" sort="Grainger, Rebecca" uniqKey="Grainger R" first="Rebecca" last="Grainger">Rebecca Grainger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Otago, Wellington, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Otago, Wellington</wicri:regionArea><wicri:noRegion>Wellington</wicri:noRegion></affiliation></author><author><name sortKey="Wallace, Zachary S" sort="Wallace, Zachary S" uniqKey="Wallace Z" first="Zachary S" last="Wallace">Zachary S. Wallace</name><affiliation wicri:level="2"><nlm:affiliation>Clinical Epidemiology Program, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Epidemiology Program, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Duarte Garcia, Ali" sort="Duarte Garcia, Ali" uniqKey="Duarte Garcia A" first="Alí" last="Duarte-García">Alí Duarte-García</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j">Arthritis & rheumatology (Hoboken, N.J.)</title><idno type="eISSN">2326-5205</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Antirheumatic disease therapies have been used to treat coronavirus disease 2019 (COVID-19) and its complications. We conducted a systematic review and meta-analysis to describe the current evidence.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A search of published and preprint databases in all languages was performed. Included studies described one or more relevant clinical outcomes in five or more people who were infected with SARS-CoV-2 and were treated with antirheumatic disease therapy between 01/01/2019 and 05/29/2020. Pairs of reviewers screened articles and extracted data and assessed risk of bias. A meta-analysis of effect sizes using the random-effects models was performed when possible.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The search identified 3,935 articles, of which 45 were included (4 randomized controlled trials, 29 cohort studies, and 12 case series). All studies evaluated hospitalized patients and 29 out of 45 had been published in a peer-reviewed journal. In a meta-analysis of three cohort studies with a low risk of bias, hydroxychloroquine use was not significantly associated with mortality (pooled hazard ratio (HR) 1.41, 95% confidence interval (CI) 0.83-2.42). In a meta-analysis of two cohort studies with some concerns/high risk of bias, anakinra use was associated with lower mortality (pooled HR 0.2, 95% CI 0.1-0.4). Evidence was inconclusive with regard to other antirheumatic disease therapies and the majority of other studies had a high risk of bias.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>In this systematic review and meta-analysis, hydroxychloroquine use was not associated with benefit or harm with regard to COVID-19 mortality. The evidence supporting the effect of other antirheumatic disease therapies in COVID-19 is currently inconclusive.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32741139</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2326-5205</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>02</Day></PubDate></JournalIssue><Title>Arthritis & rheumatology (Hoboken, N.J.)</Title></Journal><ArticleTitle>Antirheumatic Disease Therapies for the Treatment of COVID-19: A Systematic Review and Meta-analysis.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1002/art.41469</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Antirheumatic disease therapies have been used to treat coronavirus disease 2019 (COVID-19) and its complications. We conducted a systematic review and meta-analysis to describe the current evidence.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A search of published and preprint databases in all languages was performed. Included studies described one or more relevant clinical outcomes in five or more people who were infected with SARS-CoV-2 and were treated with antirheumatic disease therapy between 01/01/2019 and 05/29/2020. Pairs of reviewers screened articles and extracted data and assessed risk of bias. A meta-analysis of effect sizes using the random-effects models was performed when possible.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The search identified 3,935 articles, of which 45 were included (4 randomized controlled trials, 29 cohort studies, and 12 case series). All studies evaluated hospitalized patients and 29 out of 45 had been published in a peer-reviewed journal. In a meta-analysis of three cohort studies with a low risk of bias, hydroxychloroquine use was not significantly associated with mortality (pooled hazard ratio (HR) 1.41, 95% confidence interval (CI) 0.83-2.42). In a meta-analysis of two cohort studies with some concerns/high risk of bias, anakinra use was associated with lower mortality (pooled HR 0.2, 95% CI 0.1-0.4). Evidence was inconclusive with regard to other antirheumatic disease therapies and the majority of other studies had a high risk of bias.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this systematic review and meta-analysis, hydroxychloroquine use was not associated with benefit or harm with regard to COVID-19 mortality. The evidence supporting the effect of other antirheumatic disease therapies in COVID-19 is currently inconclusive.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Putman</LastName><ForeName>Michael</ForeName><Initials>M</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-9699-4000</Identifier><AffiliationInfo><Affiliation>Northwestern Medicine, Division of Rheumatology, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chock</LastName><ForeName>Yu Pei Eugenia</ForeName><Initials>YPE</Initials><AffiliationInfo><Affiliation>Section of Rheumatology, Yale School of Medicine, New Haven, CT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tam</LastName><ForeName>Herman</ForeName><Initials>H</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-5805-0639</Identifier><AffiliationInfo><Affiliation>Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Alfred H J</ForeName><Initials>AHJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4074-0516</Identifier><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sattui</LastName><ForeName>Sebastian E</ForeName><Initials>SE</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3945-6828</Identifier><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berenbaum</LastName><ForeName>Francis</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Sorbonne Université, INSERM CRSA, AP-HP Hopital Saint Antoine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Danila</LastName><ForeName>Maria I</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>University of Alabama at Birmingham, Birmingham, AL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Korsten</LastName><ForeName>Peter</ForeName><Initials>P</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-6065-5680</Identifier><AffiliationInfo><Affiliation>Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanchez-Alvarez</LastName><ForeName>Catalina</ForeName><Initials>C</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-6287-2213</Identifier><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sparks</LastName><ForeName>Jeffrey A</ForeName><Initials>JA</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-5556-4618</Identifier><AffiliationInfo><Affiliation>Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coates</LastName><ForeName>Laura C</ForeName><Initials>LC</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4756-663X</Identifier><AffiliationInfo><Affiliation>Patient Research Partner and Nuffield, Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palmerlee</LastName><ForeName>Candace</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Patient Research Partner and Orthopedic Manual Therapist, Private Practice, Berkeley, CA, United Kingdom of Great Britain and Northern Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peirce</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Patient Research Partner, USA, Oxford.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jayatilleke</LastName><ForeName>Arundathi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Sindhu R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital; Institute of health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kilian</LastName><ForeName>Adam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liew</LastName><ForeName>Jean</ForeName><Initials>J</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8104-2450</Identifier><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prokop</LastName><ForeName>Larry J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Library Public Services, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murad</LastName><ForeName>M Hassan</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Evidence-Based Practice Center, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grainger</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-9201-8678</Identifier><AffiliationInfo><Affiliation>Department of Medicine, University of Otago, Wellington, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallace</LastName><ForeName>Zachary S</ForeName><Initials>ZS</Initials><AffiliationInfo><Affiliation>Clinical Epidemiology Program, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duarte-García</LastName><ForeName>Alí</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1749-5719</Identifier><AffiliationInfo><Affiliation>Division of Rheumatology and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COVID-19 Global Rheumatology Alliance</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K23 AR069688</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>L30 AR066953</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R03 AR075886</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arthritis Rheumatol</MedlineTA><NlmUniqueID>101623795</NlmUniqueID><ISSNLinking>2326-5191</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antirheumatic medications</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">coronavirus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32741139</ArticleId><ArticleId IdType="doi">10.1002/art.41469</ArticleId><ArticleId IdType="pmc">PMC7435536</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>France</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Alabama</li><li>Angleterre</li><li>Basse-Saxe</li><li>Connecticut</li><li>District de Columbia</li><li>Illinois</li><li>Massachusetts</li><li>Minnesota</li><li>Missouri (État)</li><li>Ontario</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Washington (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Göttingen</li><li>Oxford</li><li>Paris</li><li>Saint-Louis (Missouri)</li><li>Seattle</li><li>Toronto</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Toronto</li><li>Université de Washington</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><noCountry><name sortKey="Palmerlee, Candace" sort="Palmerlee, Candace" uniqKey="Palmerlee C" first="Candace" last="Palmerlee">Candace Palmerlee</name></noCountry><country name="États-Unis"><region name="Illinois"><name sortKey="Putman, Michael" sort="Putman, Michael" uniqKey="Putman M" first="Michael" last="Putman">Michael Putman</name></region><name sortKey="Chock, Yu Pei Eugenia" sort="Chock, Yu Pei Eugenia" uniqKey="Chock Y" first="Yu Pei Eugenia" last="Chock">Yu Pei Eugenia Chock</name><name sortKey="Danila, Maria I" sort="Danila, Maria I" uniqKey="Danila M" first="Maria I" last="Danila">Maria I. Danila</name><name sortKey="Duarte Garcia, Ali" sort="Duarte Garcia, Ali" uniqKey="Duarte Garcia A" first="Alí" last="Duarte-García">Alí Duarte-García</name><name sortKey="Jayatilleke, Arundathi" sort="Jayatilleke, Arundathi" uniqKey="Jayatilleke A" first="Arundathi" last="Jayatilleke">Arundathi Jayatilleke</name><name sortKey="Kilian, Adam" sort="Kilian, Adam" uniqKey="Kilian A" first="Adam" last="Kilian">Adam Kilian</name><name sortKey="Kim, Alfred H J" sort="Kim, Alfred H J" uniqKey="Kim A" first="Alfred H J" last="Kim">Alfred H J. Kim</name><name sortKey="Liew, Jean" sort="Liew, Jean" uniqKey="Liew J" first="Jean" last="Liew">Jean Liew</name><name sortKey="Murad, M Hassan" sort="Murad, M Hassan" uniqKey="Murad M" first="M Hassan" last="Murad">M Hassan Murad</name><name sortKey="Prokop, Larry J" sort="Prokop, Larry J" uniqKey="Prokop L" first="Larry J" last="Prokop">Larry J. Prokop</name><name sortKey="Sanchez Alvarez, Catalina" sort="Sanchez Alvarez, Catalina" uniqKey="Sanchez Alvarez C" first="Catalina" last="Sanchez-Alvarez">Catalina Sanchez-Alvarez</name><name sortKey="Sattui, Sebastian E" sort="Sattui, Sebastian E" uniqKey="Sattui S" first="Sebastian E" last="Sattui">Sebastian E. Sattui</name><name sortKey="Sparks, Jeffrey A" sort="Sparks, Jeffrey A" uniqKey="Sparks J" first="Jeffrey A" last="Sparks">Jeffrey A. Sparks</name><name sortKey="Wallace, Zachary S" sort="Wallace, Zachary S" uniqKey="Wallace Z" first="Zachary S" last="Wallace">Zachary S. Wallace</name></country><country name="Canada"><noRegion><name sortKey="Tam, Herman" sort="Tam, Herman" uniqKey="Tam H" first="Herman" last="Tam">Herman Tam</name></noRegion><name sortKey="Johnson, Sindhu R" sort="Johnson, Sindhu R" uniqKey="Johnson S" first="Sindhu R" last="Johnson">Sindhu R. Johnson</name></country><country name="France"><region name="Île-de-France"><name sortKey="Berenbaum, Francis" sort="Berenbaum, Francis" uniqKey="Berenbaum F" first="Francis" last="Berenbaum">Francis Berenbaum</name></region></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Korsten, Peter" sort="Korsten, Peter" uniqKey="Korsten P" first="Peter" last="Korsten">Peter Korsten</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Coates, Laura C" sort="Coates, Laura C" uniqKey="Coates L" first="Laura C" last="Coates">Laura C. Coates</name></region><name sortKey="Peirce, Andrea" sort="Peirce, Andrea" uniqKey="Peirce A" first="Andrea" last="Peirce">Andrea Peirce</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Grainger, Rebecca" sort="Grainger, Rebecca" uniqKey="Grainger R" first="Rebecca" last="Grainger">Rebecca Grainger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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